Ultra-Low Dose Naltrexone

What is Ultra-Low Dose 2mcg Naltrexone?

Belmar Pharmacy’s patent-pending 2 microgram ultra-low dose naltrexone (ULDN) tablet is made at significantly lower doses than naltrexone (50-100 mg) and low dose naltrexone (1-5 mg). At commercially available strengths, naltrexone is a medication approved to treat addiction to opioids and alcohol. In contrast, ultra-low dose naltrexone compliments existing pain therapy, changing the way prescribers combat pain.

At ultra-low doses of 1-2 micrograms, our ULDN is third-party tested and has the potential to augment pain regimens by acting as a weak agonist at opioid receptor sites. It may help chronic pain patients require less opioid pain intervention, relieving pain symptoms at lower doses with less chance of dependence, tolerance, and possibly addiction.

What Are the Benefits of Ultra-Low Dose Naltrexone?

Ultra-low dose naltrexone may help patients taking prescription opioid medications for chronic pain conditions. ULDN may extend opioid analgesia and reduce tolerance and dependence to prescription opioids. Reducing dependence can offer physical advantages by decreasing common opioid side effects like constipation and drowsiness. The risk of withdrawal symptoms may also be lessened with ULDN as adjunctive therapy.

LDN use is discouraged in patients taking opioid medications because it can precipitate withdrawal symptoms by antagonizing pain receptors. Unlike LDN, ultra-low dose naltrexone can demonstrate powerful positive results when taken in conjunction with opioids.

By binding but not overwhelming the opioid pain receptors, ultra-low dose naltrexone’s weak stimulating activity may help patients with chronic pain conditions optimize their current prescription pain regimen. ULDN may enable patients to receive similar pain relief at lower opiate doses, limiting the risk of addiction potential.

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Who May Benefit from Ultra-Low Dose Naltrexone?

Ultra-low dose naltrexone can be given as an adjunctive drug for a wide range of pain conditions warranting opioid therapy, including:

• Chronic Low-Back Pain
• Osteoarthritis
• Peripheral Neuropathy
• Post-Operative Pain

ULDN may also boost patients with depleted endorphins. Increasing endorphin levels can improve energy, resilience, and sleep. The mechanistic action of ULDN is still in discovery. Additional research is underway to expand its impact.


Who Should Avoid Ultra-Low Dose Naltrexone?

Like LDN, ULDN is safe and well-tolerated. Naltrexone is not a controlled substance, meaning it is not habit-forming or addictive at any strength. Discuss with your provider if you have liver or kidney disease, or a bleeding disorder such as hemophilia.

Common Dosage Forms

At Belmar, we compound ultra-low dose naltrexone as a 2-microgram oral tablet. The tablets are scored to allow for 1-microgram dosing.

Would LDN be a better fit for your patient? Click here for more information.

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If you’re a patient, we’re here to help you fill prescriptions or provide you the information you need to work with your doctor to help decide if a compounded prescription might be a good treatment for you.

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