Pregnenolone

What is Pregnenolone?

Pregnenolone is a steroid hormone made primarily by the adrenal glands directly from cholesterol. It is the biochemical starting material in the production of most of the other steroid hormones, including progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. Pregnenolone is also a neurosteroid produced in the brain, which affects synaptic functioning, protects nerves and brain tissue, and enhances myelination. It is particularly active in the area of the brain responsible for memory. Small amounts of pregnenolone are also produced in the gonads. After about age 30, a person’s pregnenolone level steadily starts to decline.

The chemical formula for natural pregnenolone is C21H32O2. Bioidentical pregnenolone, such as that compounded by Belmar, has the same formula, structure, shape, and functioning in the body. Several synthetic ester derivatives of pregnenolone also exist, but with different formulas, and similar but different functioning.

Who May Benefit From Pregnenolone Supplementation?

Women and men with hormonal imbalances

Low doses of pregnenolone may help enhance the treatment of other steroid hormone deficiencies. For example, it can support other hormone treatments in reducing uncomfortable symptoms of menopause or andropause.

People with memory issues

Low pregnenolone levels are associated with declining memory function and declining mental awareness. Pregnenolone supplementation may improve memory and cognitive function, including multi-tasking under stress. It may help raise brain levels of the neurotransmitter acetylcholine.

People with depression or certain other psychiatric conditions

Pregnenolone may help relieve depression in certain patients, either through its effects on alertness and mental stimulation or by treating abnormalities in particular components of brain cells. Pregnenolone affects many chemicals in the brain and may play a role in conditions such as schizophrenia or bipolar disorder.

Dosage and Form

The following dosage forms and strengths of testosterone and testosterone combinations currently fall within our formulary:

Medication  Form Strengths
Pregnenolone Tablet 25-200mg/tablet
Pregnenolone Fast-burst Sublingual Tablets 10-30mg/tablet

How Belmar Can Help

If you’re a clinician interested in prescribing compound medications to your patients, contact us for information on how to get started and to access all of our clinical resources. If you are new to compounding, you may find our page on How to Write a Compounding Prescription helpful. You can also visit our Treatment Options page to find a formulary and learn more about all the medication solutions available from Belmar.

Contact Belmar Pharma Solutions

Learn More

If you’re a patient, we’re here to help you fill prescriptions or provide you the information you need to work with your doctor to help decide if a compounded prescription might be a good treatment for you.

Prescribers, for a complete formulary or access to our clinical resources fill out the form below and one of our Solutions Engineers will be in touch shortly. If you are new to compounding, you may also find our page on How to Write a Compounding Prescription helpful.


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Thank you for reaching out. A member of our team is reviewing your message and will reach out as soon as possible. In the meantime, below are a few links, including our formulary, that we think you might find helpful:

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Thank you for reaching out. A member of our team is reviewing your message and will reach out as soon as possible. In the meantime, below are a few links, including our formulary, that we think you might find helpful:

Formulary
Treatment Options
Clinician Blog