Sermorelin: A New Approach to Anti-Aging and Weight Loss Therapy

The body changes with aging for women and men alike, and some of these body changes cannot be avoided. However, there are ways in which doctors can assist patients maintain the best quality of life possible, as they age (chronologically that is).

Throughout the aging process, hormone levels start to fluctuate. In men, testosterone levels begin to decline around thirty years old. Testosterone replacement therapy can be a great approach to improve men’s overall health. Sermorelin also helps men and women address hormonal imbalances that come with age. 

Sermorelin is a growth hormone-releasing hormone (GHRH) essential for overall growth, cell regeneration, and cell reproduction. Sermorelin is approved by the FDA to treat Adult Growth Hormone Deficiency (AGHD) and growth problems in children. Sermorelin naturally prompts the pituitary gland to make and release natural human growth hormone (HGH).

A deficiency of growth hormones in adults may lead to undesirable health issues, including reduced vitality, a decrease in muscle mass, weight gain, and decreased energy.

Sermorelin is widely used as a weight loss and anti-aging supplement that aids the body in repairing damaged cells and weakened systems caused by insufficient human growth hormone (HGH). The levels of HGH secretion gradually deteriorate with aging causing a decrease in lean body mass, increase in body fat, adverse changes in lipoproteins, and a reduction in aerobic capacity.

Some of the benefits of Sermorelin may be:

• Supports immune system functioning;
• Plays a key role in sleep regulation;
• Improvement in sexual performance and libido;
• Greater strength and higher energy levels;
• Growth of lean muscle mass and weight loss;
• Bone health;
• Skin and nail health.

If you are a prescriber and are interested in prescribing these medications, please complete this form and a Belmar Solutions Engineer will reach out to you.

---

REFERENCES:

Barabutis N. A glimpse at growth hormone–releasing hormone cosmos. Clinical & Experimental Pharmacology & Physiology. 2020;47(9):1632-1634. Accessed January 11, 2022. https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,sso&db=s3h&AN=145052239&site=eds-live&scope=site

Chang Y, Huang R, Zhai Y, et al. A potentially effective drug for patients with recurrent glioma: sermorelin. ANNALS OF TRANSLATIONAL MEDICINE. 2021;9(5):20-6561. doi:10.21037/atm-20-6561

Cummings DE, Merriam GR. Age-related changes in growth hormone secretion: should the somatopause be treated?. Semin Reprod Endocrinol. 1999;17(4):311-325. doi:10.1055/s-2007-1016241

Frieboes, R. M., Schier, T., Guldner, J., Colla-Müller, M., Murck, H., & Steiger, A. (1995). [Action of growth hormone releasing hormone (GHRH) on sleep EEG and nocturnal secretion of growth hormone, cortisol and ACTH in patients with major depression]. Wiener Medizinische Wochenschrift (1946), 145(17–18), 499–500.

Fukuda I, Hizuka N, Muraoka T, Ichihara A. Adult growth hormone deficiency: current concepts. Neurol Med Chir (Tokyo). 2014;54(8):599-605. doi:10.2176/nmc.ra.2014-0088

Prakash A, Goa KL. Sermorelin: A Review of its Use in the Diagnosis and Treatment of Children with Idiopathic Growth Hormone Deficiency. BioDrugs. 1999;12(2):139-157. Accessed January 11, 2022. https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,sso&db=asn&AN=9522602&site=eds-live&scope=site

Seitz S, Hohla F, Schally AV, et al. Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist. Oncol Rep. 2008;20(5):1289-1294.

Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clinical interventions in aging. 2006;1(4):307-308. doi:10.2147/ciia.2006.1.4.307

Zhang C, Cai R, Lazerson A, et al. Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin. Lung. 2019;197(5):541-549. doi:10.1007/s00408-019-00257-w

Zhang C, Cui T, Cai R, et al. Growth Hormone-Releasing Hormone in Lung Physiology and Pulmonary Disease. Cells. 2020;9(10). doi:10.3390/cells9102331