Sexual Wellness

Andropause and Periandropause – A Clinical Perspective. Why Should We Treat Them, And How?

January 15, 2022

By: Belmar Pharmacy

Women are not the only ones who struggle with hormonal changes. As they age, men also undergo their own version of menopause, called andropause. In andropause, men may experience symptoms like erectile dysfunction, low sex drive, irritability, lack of energy, fatigue, loss of memory, sleep disorder, loss of muscle mass, depression, and infertility due to low testosterone.

Periandropause usually happens when a man’s hormonal level starts to decline. A gradual decline in testosterone levels begins at about 30 years old when testosterone level starts to fall by about 1 percent each year. Between ages 50 and 80, the standard level of bioavailable testosterone drops more than 50%.

Why should we provide a solution for them?

Here are some reasons why doctors should consider treating their patients:

  • Testosterone deficiency is associated with several cardiovascular risk factors that include obesity, insulin resistance, dyslipidemia, and hypertension.
  • Low testosterone levels are associated with the presence and degree of atherosclerosis.
  • Testosterone deficiency hinders the anatomical and physiological/ biochemical substrate of erectile capacity.
  • Men with obesity and type 2 diabetes have a high prevalence of testosterone deficiency.
  • Studies have shown that testosterone therapy reduces total cholesterol levels significantly and improves the ratio of high-density lipoprotein (HDL) to low- density lipoprotein (LDL).

What solutions are available?

Androgens like testosterone perform an important role in the health and wellbeing of men. And while androgen decline in aging men is a fact of life, it does not need to be an unavoidable consequence of aging. Testosterone replacement therapy can provide relief to testosterone deficiency symptoms and improve men’s overall health.

Testosterone replacement therapy can also help older men to prevent the increase in body fat, inhibit muscle loss, and increase lean body mass. Androgen therapy improves the intracellular utilization of amino acids, the building blocks for proteins, and prompts an increase in skeletal muscle protein synthesis.

Belmar Pharma Solutions compounds bioidentical testosterone produced from plant-based sources and has the same molecular structure as the natural testosterone produced by the human body. If you are a physician interested in prescribing compounded testosterone to your patients, contact us for information on how to get started and to access all of our clinical resources.


Segal SJ, Mastroianni L. Hormone Use in Menopause & Male Andropause. [Electronic Resource] : A Choice for Women and Men. Oxford University Press; 2003. Accessed November 16, 2021.,sso&db=cat08964 a&AN=gvsu.ebs12476729e&site=eds-live&scope=site

Jones TH. Testosterone Deficiency in Men. OUP Oxford; 2008. Accessed November 16, 2021.,sso&db=nlebk&A N=467558&site=eds-live&scope=site

Caliber M, Saad F. Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone. Current opinion in pharmacology. 2021;58:83-89. doi:10.1016/j.coph.2021.04.002

If you are a prescriber and are interested in prescribing these medications, please complete this form and a Belmar Solutions Engineer will reach out to you.