Physical, psychological, social, and intimate relationships each play a role in men’s sexual health and wellness. For men in good physical and mental health, regardless of age, having a healthy sex life can contribute positively to overall happiness and longevity. However, experiencing erectile dysfunction (ED), premature ejaculation, or other sexual wellness concerns can adversely affect intimate relationships and put a strain on one’s emotional well-being.

With age, many men experience issues like low libido, weak physical response to arousal, ED, and fatigue. This can affect their sex life as well as their confidence. While there are many factors involved, low testosterone may be one of the root causes of men’s sexual health concerns.

Hormones naturally decline with age, but that doesn’t mean your best days are behind you when it comes to sex and relationships. Belmar Pharma Solutions offers numerous ways to optimize hormones and address sexual dysfunction in men, including erectile dysfunction medications.

men's sexual health man smiling

Men’s Sexual Health Therapies

Bremelanotide Acetate

Bremelanotide is a nonselective melanocortin receptor agonist that activates several receptor types to influence brain pathways involved in sexual response.

Sildenafil Citrate

Sildenafil citrate is a PDE5 inhibitor that may be used to support erectile function and may help manage pulmonary arterial hypertension.

Tadalafil

Tadalafil is a PDE5 inhibitor that may help increase smooth muscle relaxation and blood flow.

Gonadorelin Acetate

Gonadorelin is a synthetic form of the body’s natural gonadotropin releasing hormone (GnRH) that may stimulate the release of luteinizing hormone.

Oxytocin

Oxytocin is a natural hormone and neurotransmitter that supports key reproductive functions and influences bonding and social behavior.

Pregnenolone

Pregnenolone is a cholesterol-derived steroid precursor produced in the adrenal glands and brain that supports vital functions like hormone synthesis, nerve protection, and memory.

Phenylephrine HCL

Phenylephrine is used as a rescue medication for priapism. It works by tightening blood vessels in the penis so the trapped blood can drain, helping the erection go down.

Alprostadil / Papaverine HCL / Phentolamine Mesylate (TriMix)

Tri Mix penile injection combines alprostadil, papaverine, and phentolamine which may offer a fast‑acting option that supports stronger and more reliable erections when oral medications are not achieving desired results.

Papaverine HCL / Phentolamine Mesylate (BiMix)

Papaverine and phentolamine (Bi Mix injection) relaxes cavernosal smooth muscle to enhance penile blood flow and promote tumescence.

Enclomiphene Citrate

Enclomiphene citrate is a selective estrogen receptor modulator that blocks estrogen feedback in the pituitary, which may raise LH and FSH levels.

DHEA

Dehydroepiandrosterone (DHEA) is an adrenal steroid and a key precursor hormone to androgens like testosterone and estrogens such as estradiol, with levels peaking at early adulthood before steadily declining with age.

Clomiphene Citrate

Clomiphene is a selective estrogen receptor modulator (SERM) that increases the release of LH and FSH by blocking estrogen feedback in the brain.

Testosterone Cypionate / Anastrozole Grapeseed Oil

A testosterone cypionate/anastrozole in grapeseed oil may support hormone balance and limit excess conversion of testosterone into estradiol.

Testosterone Cypionate / DHEA Grapeseed Oil

A testosterone cypionate/DHEA grapeseed oil injection combines long‑acting testosterone with DHEA, a hormone that the body can naturally convert into other hormones.

Testosterone

Testosterone is a sex hormone that plays a number of important roles in reproductive health and general wellness in both women and men.

Anastrozole

Anastrozole is a nonsteroidal aromatase inhibitor that blocks the enzyme aromatase, limiting the conversion of testosterone to estrogen in peripheral tissues.

About Men’s Sexual Health and Wellness

men's sexual health erectile dysfunction man running on trail

Overview

Two of the most common forms of sexual dysfunction in men are erectile dysfunction (ED) and premature ejaculation.

ED means difficulty getting or keeping an erection for intercourse. Erectile dysfunction can occur at any age. Studies show it affects about half of American men over age 40.

Premature ejaculation refers to ejaculating before or shortly after sexual penetration, much sooner than you or your partner would like.

 

Causes

Sexual responses are complex interactions of your mind and your nervous, circulatory, and hormonal systems. Sexual dysfunction and low sex drive in men can be caused by physical or psychological reasons or a combination of these factors.

Physical reasons for erectile dysfunction and/or premature ejaculation may include:

  • Low testosterone levels or other hormonal imbalances
  • Heart or blood vessel disease, such as clogged arteries, and high blood pressure
  • Nerve disorders
  • Diabetic nerve damage
  • Obesity
  • Chronic kidney or liver diseases
  • Smoking
  • Heavy drinking or long-term drug use
  • Parkinson’s disease
  • Multiple sclerosis
  • Treatments for prostate cancer or enlarged prostate
  • Injury to the penis

Psychological causes may include:

  • Relationship problems
  • Depression, anxiety
  • Past sexual trauma or feelings of guilt about sex
  • Work-related stress
  • Low self-confidence
  • Performance anxiety

Additionally, low hormone levels, including oxytocin, may be factors, as well as low levels of the chemicals serotonin and dopamine (which contribute to sexual desire and excitement).

Prescription drugs (antidepressants, high blood pressure medicines, antihistamines, adderall) can also cause or worsen sexual dysfunction symptoms.

 

Symptoms

One of the most common symptoms of erectile dysfunction in men is inability to get or maintain an erection firm enough for satisfying sexual activity. Low sex drive and premature ejaculation are other signs of ED. While most men experience occasional symptoms of ED at some point in their lives, recurring symptoms could be signs of a medical condition or the result of age-related hormone decline, particularly low testosterone.

The only symptom of premature ejaculation is ejaculating before or shortly after sexual penetration, much sooner than either partner would like.

Diagnosis

Diagnosis for erectile dysfunction may involve a physical exam and a discussion with your healthcare provider about your medical and sexual history. Your provider may also check your prostate, blood pressure, and conduct blood tests for hormone levels, blood sugar, and cholesterol. Depending on the results, your prescriber may recommend erectile dysfunction medication or send you to a specialist such as a urologist, endocrinologist, sex therapist, or other counselor to address any underlying physical or psychological problems.

A premature ejaculation diagnosis typically involves an appointment with a urologist. You may undergo a physical exam as well as discussion about your experiences, including frequency and other circumstances involving premature ejaculation. Your provider may also ask about medications you’re taking and alcohol and drug use.

Commonly Asked Questions About Men’s Sexual Health

|

The natural aging process and decline in testosterone levels by about 1.5% each year from age 30 on may cause low sex drive in men. A man’s physical health, emotional well-being, stress levels, and lifestyle may all contribute to low libido, as well. Men with diabetes, high blood pressure, sleep disorders, or anxiety and depression may also find that they think about and desire sex less than usual. Alcohol and drug use can also cause low sex drive in men, and tobacco use may damage blood vessels and suppress testosterone levels over time.

Lifestyle changes, such as improving sleep habits, reducing stress, regular exercise, and eating a healthy diet may help increase sex drive in men. However, low testosterone levels don’t replenish themselves; they only continue to decline naturally with age. For men in andropause, bioidentical hormone replacement therapy (BHRT) that includes a combination of testosterone, DHEA, and even oxytocin, may help boost male sex drive long term.

Belmar Pharmacy offers a variety of dosage forms and customizable strengths for medications that address men’s sexual dysfunction. Bioidentical hormone replacement therapy (BHRT) is available in the form of oral medications, topical creams, and injectable combinations. Oral medications like sildenafil citrate, vardenafil, and tadalafil, are designed to help men get and maintain an erection for satisfying sexual intercourse. Injectable testosterone therapies help increase hormone levels, and intracavernosal injections are injected directly into the penis to produce a more immediate result than other types of sexual dysfunction medications.

Hormone pellets are a unique delivery form created to replicate how hormones are naturally released in the body as closely as possible. In a simple office procedure, these rice-grain-sized pellets are inserted under a patient’s skin near the hip area.

Delivering hormone replacement therapy in pellet form has multiple benefits:

  • Convenience: No need to worry about remembering to take daily medication. Hormone pellets may only need to be inserted 3 to 4 times per year.
  • Minimal side effects: Pellet therapy sends hormones into the bloodstream, avoiding potential side effects of oral medications.
  • Consistency: Pellets are designed to supply a consistent level of hormones in the bloodstream.

Bioidentical hormones, like the ones Belmar Pharmacy compounds, are used to treat men (and women) with low hormone levels. Bioidentical hormone pellets have the same molecular structure as natural human hormones, so they work the same way and are readily absorbed by the body.

Replenishing testosterone through pellets may improve men’s sexual wellness, including increasing libido and helping with erectile dysfunction.

A medical provider will likely begin by asking questions about current symptoms, as well as a medical and sexual history. Given the topic, the questions will get personal, but don’t sink into embarrassment. Answering truthfully is important.

A physical exam can follow that could include an examination of the penis and testicles, a rectal exam to check the prostate, a blood pressure check, as well as blood tests for hormone levels, blood sugar, and cholesterol. Depending on the results, the prescriber may recommend medication(s) or coordinate a consultation from a specialist such as a urologist, endocrinologist, sex therapist, or other counselor to address any underlying physical or psychological problems.

Testosterone levels drop roughly 1% each year after age 30, for many men. This can lead to lower libido and a decrease in nitric oxide (N.O.) production, which is needed for an erection.

But low testosterone may only play a small role in ED. Testosterone is connected to a man’s desire for sexual activity (libido), which in turn triggers dopamine and oxytocin release from the brain to increase N.O. for an erection. In most cases there are other underlying causes for ED. As patients get older, disease states are often the primary culprit for ED, with decreased testosterone being just one contributing factor.

Many conditions can be connected to ED, such as diabetes, high blood pressure, depression, high cholesterol, and cardiovascular disease. These health issues affect blood flow, nitric oxide production, and nerve signaling necessary to stimulate an erection. Improving the underlying causes that relate to erectile dysfunction, may also help restore sexual function. If the patient is generally considered healthy and ED is the only complaint, it’s a sign to the provider to look deeper for cardiovascular issues. ED can be a precursor to cardiovascular events down the road.

Patients with an increased risk of priapism – erections lasting 4 hours or more – should seek medical advice before starting injectable medications for erectile dysfunction. Conditions like sickle cell disease, leukemia, and multiple myeloma can be predisposed to priapism and are encouraged to discuss appropriateness of therapy with a provider. Use is contraindicated for those with Peyronie’s disease, bleeding disorders, or recurrent priapism.

Patients with higher likelihood for priapism should also discuss risk management, such as rescue medications, for emergent situations. Injectable phenylephrine can serve as a therapeutic option for these cases.

There are other conditions that may affect candidacy for compounded erectile dysfunction injectable medications. Reach out to a medical provider to discuss appropriate therapies.

Prescription drugs such as antidepressants, high blood pressure medicines, or antihistamines, may cause or worsen sexual dysfunction symptoms. If there are concerns that current medications may be negatively affecting sexual wellbeing, contacting a medical professional is recommended.

Low sex drive in men is especially common during andropause. Compounded hormone replacement therapy (HRT) can target libido changes and support sex drive. Consultations with a compounding pharmacist will explain the hormonal challenges of advancing age and share therapeutic options, like testosterone and oxytocin.

Low sex drive and erectile dysfunction can both be consequences of aging and andropause, but they are not the same thing. Having low sex drive means experiencing little to no desire for sex, whereas erectile dysfunction is difficulty achieving or maintaining an erection sufficient for sexual intercourse.

They can be connected, though. As men get older, hormone levels begin to drop. For many men, testosterone levels drop roughly 1% each year after age 30. This can lead to lower libido and a decrease in erectile function.

Low sex drive can happen at any time and it’s easy to misplace blame. Both women and men can experience it, though embarrassment and shame can prevent partners from talking about it. The goal is to build intimacy and foster connection so couples can address low sex drive together, whether the cause is psychological or physiological (or both).

Related Insights

Blog
Patients

Ask the Pharmacist — International Men’s Day: Testosterone Replacement Therapy Edition

In honor of International Men’s Day, we whipped up a special edition of Ask the Pharmacist with our very own […]

Blog
Clinicians

Why Compounded Medications Matter: How Belmar Pharmacy Helps Providers Deliver Personalized Care 

At Belmar Pharmacy, we’ve spent the last 40 years perfecting the art and science of compounded medications and creating personalized […]

Webinar
Clinicians

Sexual Wellness & Ongoing Intimacy Support

Take an in-depth look at supporting your patients’ sexual wellness now and long term.  Belmar Pharma Solutions’ Preferred Provider Webinar […]

Blog
Patients

ED: Your Voice Matters More Than You Think

Have you ever felt undesired by your partner? Does your once satisfying intimate life now feel strained and disconnected?  It’s […]

physioage webinar erectile dysfunction
Webinar
Clinicians

Erectile Dysfunction: An In-Depth Look at Hormone Therapies

Belmar Pharma Solutions’ FREE Educational Webinar Series proudly presents “Erectile Dysfunction: An In-Depth Look at Hormone Therapies” webinar hosted by […]

male sexual health image of a man smiling
Webinar
Clinicians

Current Innovations in Male Sexual Health

Dr. Angela DeRosa DO, MBA, CPE discusses male sexual health as it relates to foundational and performance therapies; including hormone […]

Get Started

Submit a Prescription

Become a Provider

Submit an Inquiry