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Erectile Dysfunction Sterile Injectable Medications
January 3, 2024
What Is Erectile Dysfunction? Erectile dysfunction (ED) is defined as difficulty achieving or maintaining an erection sufficient for sexual intercourse. […]
Tadalafil
Tadalafil is a PDE5 inhibitor that may help increase smooth muscle relaxation and blood flow.
Common dosage forms
Capsule
Cream
Fast SL
Gel
Oral Tablet
Troche
What is Tadalafil?
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor that may enhance the body’s natural response to sexual stimulation by promoting smooth‑muscle relaxation and improving blood flow in targeted tissues. In adult men with erectile dysfunction (ED), this improved circulation may support a stronger, more sustained erectile response during arousal and help maintain an erection sufficient for sexual intercourse.
Beyond oral use, tadalafil may also be compounded into topical preparations—often referred to as “scream creams”—that are applied directly to genital tissues. In women, these topical formulations may help increase local blood flow to the clitoris and vaginal tissues, potentially enhancing sensitivity, natural lubrication, and overall sexual comfort.
Who May Benefit from Tadalafil Therapy?
Male Erectile Dysfunction
Tadalafil may benefit adult men who need support enhancing the natural erectile response during sexual stimulation. By increasing blood flow to penile tissue, the medication can help the body maintain a firmer response and achieve an erection sufficient for intercourse when arousal occurs.
Female Sexual Support
Topical tadalafil may benefit women who need support improving blood flow to vaginal tissues, which may help enhance natural lubrication and comfort during sexual activity. Referred to as ‘scream creams,’ these preparations may enhance sexual experience.
Sexual Dysfunction Associated with Certain Medications
Prescription drugs such as antidepressants may cause or worsen sexual dysfunction symptoms. If there are concerns that current medications may be negatively affecting sexual wellbeing, contacting a medical professional is recommended. Tadalafil may help adults who develop sexual dysfunction while taking antidepressants, provided a clinician has evaluated the situation and deemed its use appropriate.
Access clinical studies on Tadalafil
- Rosen RC, Wu F, Behre HM, et al. Quality of Life and Sexual Function Benefits of Long-Term Testosterone Treatment: Longitudinal Results From the Registry of Hypogonadism in Men (RHYME). J Sex Med, 2017;14(9):1104-1115.
- Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, Maggi M, Nelson CJ, Parish S, Salonia A, Tan R, Mulhall JP, Hellstrom WJ. Erectile dysfunction. Nat Rev Dis Primers. 2016 Feb 4;2:16003.
- Corona G, Rastrelli G, Morgentaler A, et al. Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores. Eur Urol, 2017; 72(6):1000-1011.
- Hsiao W, Bennett N, Guhring P, Narus J, Mulhall JP. Satisfaction profiles in men using intracavernosal injection therapy. J Sex Med. 2011 Feb;8(2):512-7.
- Hatzimouratidis K, Salonia A, Adaikan G, Buvat J, Carrier S, El-Meliegy A, McCullough A, Torres LO, Khera M. Pharmacotherapy for Erectile Dysfunction: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med. 2016 Apr;13(4):465-88.
- Jannini EA, Nappi RE. Couplepause: A New Paradigm in Treating Sexual Dysfunction During Menopause and Andropause. Sex Med Rev. 2018 Jul;6(3):384-395.
Access package inserts for Tadalafil
Commonly Asked Questions
Sildenafil citrate and tadalafil are both oral phosphodiesterase 5 inhibitors (PDE5) inhibitors. Sildenafil effects usually start within 30–60 minutes and may last about 4–6 hours, while tadalafil may take longer to initiate effects but tends to have a longer duration of action. Tadalafil also offers daily low‑dose options and tends to provide more flexibility due to its prolonged activity.
Tadalafil works by inhibiting the PDE5 (phosphodiesterase 5) enzyme, which may increase levels of cGMP and support smooth muscle relaxation and blood flow in specific tissues. It is used for erectile dysfunction and may also be used in certain off‑label situations, such as female sexual dysfunction.
Yes, tadalafil may slightly lower blood pressure because it relaxes and widens blood vessels, which can cause a mild drop in pressure. For most healthy adults this effect is usually small, but the drop can be more significant when tadalafil is combined with nitrates or certain blood pressure‑lowering medications.
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Erectile Dysfunction: An In-Depth Look at Hormone Therapies
December 8, 2023
Belmar Pharma Solutions’ FREE Educational Webinar Series proudly presents “Erectile Dysfunction: An In-Depth Look at Hormone Therapies” webinar hosted by […]
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