At Belmar Pharma Solutions, we work with low dose naltrexone (LDN) every day. Our pharmacists answer questions about low dose naltrexone from prescribers like you, and from patients who want more information before approaching their providers about the medication.
You probably have patients in your practice right now who may benefit from receiving LDN for their health conditions. Let’s look at some potential benefits that compounded LDN has for the people who trust you to help them feel better.
LDN can be prescribed for myriad conditions
Many practitioners are familiar with naltrexone use in opioid and alcohol addiction, typically at doses of around 50 milligrams. Compounded low dose naltrexone is prescribed in much smaller doses of 1 to 5 milligrams per day.
LDN works in several ways giving it a wide range of uses across multiple disease states. It can boost endorphins, which is thought to help regulate the immune system and enhance the immune response. LDN can also suppress excitatory cytokines, which decreases pain and has an anti-inflammatory effect.
Clinical reports show possible benefits for conditions like chronic pain, fibromyalgia, Crohn’s disease, and multiple sclerosis. (1)
LDN’s immune-modulating effects may benefit those with autoimmune diseases such as Hashimoto’s thyroiditis and rheumatoid arthritis. (2)
In people with long COVID, studies show LDN may reduce the persistent fatigue and brain fog experienced by some patients. (3,4)
LDN is typically well-tolerated
Many patients are eligible for LDN, as there are no contraindications. When started low and then advanced slowly to find the optimal dose, LDN is usually well-tolerated. Most patients experience minimal, if any, side effects. (2)
Compounded LDN works for patients with allergies or sensitivities to excipients
At Belmar, we use only necessary ingredients to help patients with allergies or sensitivities to certain fillers. We also have customizable LDN capsules, sublingual tablets, and suspensions. Our wide range of strengths and dosage forms for compounded LDN means we’re likely to have a formula that meets your patients’ needs.
Our compounded LDN tablets are third-party tested
All of the ingredients in Belmar’s compounded LDN and other prescription therapies are purchased from FDA registered facilities. As part of our exceptional quality and safety practices, we perform third-party testing to ensure potency.
With multiple LDN certified specialists on our pharmacy team, we offer clinical support to our providers. When you prescribe LDN, our pharmacists can guide your practice through dosing titrations geared specifically for each individual patient.
LDN can make a real difference in well-being
When patients live with the chronic conditions mentioned above, they can have a reduced quality of life due to pain, fatigue, or other symptoms. With LDN on board, imagine the positive effects that pain relief or more restful sleep could have on a person’s overall wellness.
To learn more about the potential benefits of LDN for your patients, watch our clinician webinar, “The Lowdown on LDN” and read our clinician article, “Long Live Low Dose Naltrexone.”
References for new info:
1. Toljan K, Vrooman B. Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization. Med Sci (Basel). 2018;6(4):82. doi: 10.3390/medsci6040082.
Link: Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization – PMC
2. The Lowdown on Low Dose Naltrexone and Chronic Conditions. Belmar Pharma Solutions. March 2025. Accessed June 15, 2025.
3. O’Kelly B, Vidal L, McHugh T, Woo J, Avramovic G, Lambert JS. Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study. Brain Behav Immun Health. 2022 Oct;24:100485. doi: 10.1016/j.bbih.2022.100485.
Link: Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study – PMC
4. Isman A, Nyquist A, Strecker B, et al. Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19. Brain Behav Immun Health. 2024 Feb 1;36:100733. doi: 10.1016/j.bbih.2024.100733.
Link: Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19 – PMC
